Veno-arterial extracorporeal membrane oxygenation as a bridge to recovery in a patient with cardiogenic shock due to acute left main coronary artery occlusion

    Authors

    Keywords

    heart failure, cardiogenic shock, acute coronary syndrome, extracorporeal membrane oxygenation, left main coronary artery

    DOI

    https://doi.org/10.15836/ccar.2015.233

    Full Text

    Introduction: Coronary artery disease represents the most common cause of morbidity and mortality in developed countries. With the introduction of percutaneous coronary interventions (PCI) and the primary PCI network, the mortality of acute myocardial infarction (MI) has significantly decreased. However, patients with acute MI complicated with severe acute heart failure still show poor outcomes. Circulatory support with extracorporeal membrane oxygenation (ECMO) in such patients may serve as either bridge-to-recovery or bridge-to-decision treatment modality. This case highlights the importance of early recognition of the need for ECMO support as well as its early implantation in acute MI complicated with severe acute heart failure. ( 1 - 3 ) Case report: A 64-year-old male patient was hospitalized in Coronary Care Unit due to acute anteroseptolateral ST segment elevation myocardial infarction with signs of cardiogenic shock and pulmonary oedema. Echocardiography showed severely reduced systolic function of left ventricle. Inotropic and vasopressor support was initiated. The patient was intubated and mechanically ventilated. Coronary angiogram revealed acute thrombotic occlusion of left main coronary artery (LMCA). Due to the angiography finding and hemodynamic instability, veno-arterial (V-A) ECMO support was introduced, under which a successfull PCI of LMCA was done. Soon after the vessel recanalization, patient became normotensive and both inotropic as well as vasopressor therapy was gradually discontinued. Chronic heart failure therapy was progressively introduced (spironolactone, ACE inhibitor, and finally beta-blocker). Patient was successfully weaned from ECMO support six days after the implantation, without any complications. Three months later the patient is in NYHA I functional status, with a significant improvement in ECHO finding (LVEF 45%). Control coronary angiography revealed significant restenosis in the previously implanted BMS and the re-PCI of LMCA with DES and re-PTCA of proximal LAD with DEB was successfully performed under the IVUS control. Conclusion: V-A ECMO is a life-saving therapy in patients treated with PCI in the setting of acute MI complicated with cardiogenic shock. It may serve as a bridge to myocardial recovery, cardiac transplantation or implantation of long-term left ventricular assist device. It is of outmost importance to recognize the need for ECMO support on time, in order to improve the clinical outcome after successful coronary revascularization.

    Cardiologia Croatica
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    Veno-arterial extracorporeal membrane oxygenation as a bridge to recovery in a patient with cardiogenic shock due to acute left main coronary artery occlusion

    Abstract
    Issue9-10
    Published
    Pages233
    PDF via DOIhttps://doi.org/10.15836/ccar.2015.233
    heart failure
    cardiogenic shock
    acute coronary syndrome
    extracorporeal membrane oxygenation
    left main coronary artery

    Authors

    Petra Angebrandt*ORCIDCroatia
    Marijan PašalicORCIDCroatia
    Ivo PlanincORCIDCroatia
    Dora FabijanovicORCIDCroatia
    Maja CikešORCIDCroatia
    Hrvoje JurinORCIDCroatia
    Zeljko BaricevicORCIDCroatia
    Jure SamardzicORCIDCroatia
    Davor MilicicORCIDCroatia
    Boško SkoricORCIDCroatia

    Full Text

    Introduction: Coronary artery disease represents the most common cause of morbidity and mortality in developed countries. With the introduction of percutaneous coronary interventions (PCI) and the primary PCI network, the mortality of acute myocardial infarction (MI) has significantly decreased. However, patients with acute MI complicated with severe acute heart failure still show poor outcomes. Circulatory support with extracorporeal membrane oxygenation (ECMO) in such patients may serve as either bridge-to-recovery or bridge-to-decision treatment modality. This case highlights the importance of early recognition of the need for ECMO support as well as its early implantation in acute MI complicated with severe acute heart failure. ( 1 - 3 ) Case report: A 64-year-old male patient was hospitalized in Coronary Care Unit due to acute anteroseptolateral ST segment elevation myocardial infarction with signs of cardiogenic shock and pulmonary oedema. Echocardiography showed severely reduced systolic function of left ventricle. Inotropic and vasopressor support was initiated. The patient was intubated and mechanically ventilated. Coronary angiogram revealed acute thrombotic occlusion of left main coronary artery (LMCA). Due to the angiography finding and hemodynamic instability, veno-arterial (V-A) ECMO support was introduced, under which a successfull PCI of LMCA was done. Soon after the vessel recanalization, patient became normotensive and both inotropic as well as vasopressor therapy was gradually discontinued. Chronic heart failure therapy was progressively introduced (spironolactone, ACE inhibitor, and finally beta-blocker). Patient was successfully weaned from ECMO support six days after the implantation, without any complications. Three months later the patient is in NYHA I functional status, with a significant improvement in ECHO finding (LVEF 45%). Control coronary angiography revealed significant restenosis in the previously implanted BMS and the re-PCI of LMCA with DES and re-PTCA of proximal LAD with DEB was successfully performed under the IVUS control. Conclusion: V-A ECMO is a life-saving therapy in patients treated with PCI in the setting of acute MI complicated with cardiogenic shock. It may serve as a bridge to myocardial recovery, cardiac transplantation or implantation of long-term left ventricular assist device. It is of outmost importance to recognize the need for ECMO support on time, in order to improve the clinical outcome after successful coronary revascularization.