Authors

• Petra Angebrandt — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0001-5431-9736
• Marijan Pašalic — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0002-3197-2190
• Ivo Planinc — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0003-0561-6704
• Dora Fabijanovic — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0003-2633-3439
• Maja Cikeš — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0002-4772-5549
• Hrvoje Jurin — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0002-2599-553X
• Zeljko Baricevic — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0002-5420-2324
• Jure Samardzic — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0002-9346-6402
• Davor Milicic — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0001-9101-1570
• Boško Skoric — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0001-5979-2346

Abstract

Introduction: Coronary artery disease represents the most common cause of morbidity and mortality in developed countries. With the introduction of percutaneous coronary interventions (PCI) and the primary PCI network, the mortality of acute myocardial infarction (MI) has significantly decreased. However, patients with acute MI complicated with severe acute heart failure still show poor outcomes. Circulatory support with extracorporeal membrane oxygenation (ECMO) in such patients may serve as either bridge-to-recovery or bridge-to-decision treatment modality. This case highlights the importance of early recognition of the need for ECMO support as well as its early implantation in acute MI complicated with severe acute heart failure. (1-3) Case report: A 64-year-old male patient was hospitalized in Coronary Care Unit due to acute anteroseptolateral ST segment elevation myocardial infarction with signs of cardiogenic shock and pulmonary oedema. Echocardiography showed severely reduced systolic function of left ventricle. Inotropic and vasopressor support was initiated. The patient was intubated and mechanically ventilated. Coronary angiogram revealed acute thrombotic occlusion of left main coronary artery (LMCA). Due to the angiography finding and hemodynamic instability, veno-arterial (V-A) ECMO support was introduced, under which a successfull PCI of LMCA was done. Soon after the vessel recanalization, patient became normotensive and both inotropic as well as vasopressor therapy was gradually discontinued. Chronic heart failure therapy was progressively introduced (spironolactone, ACE inhibitor, and finally beta-blocker). Patient was successfully weaned from ECMO support six days after the implantation, without any complications. Three months later the patient is in NYHA I functional status, with a significant improvement in ECHO finding (LVEF 45%). Control coronary angiography revealed significant restenosis in the previously implanted BMS and the re-PCI of LMCA with DES and re-PTCA of proximal LAD with DEB was successfully performed under the IVUS control. Conclusion: V-A ECMO is a life-saving therapy in patients treated with PCI in the setting of acute MI complicated with cardiogenic shock. It may serve as a bridge to myocardial recovery, cardiac transplantation or implantation of long-term left ventricular assist device. It is of outmost importance to recognize the need for ECMO support on time, in order to improve the clinical outcome after successful coronary revascularization.

Keywords

heart failure, cardiogenic shock, acute coronary syndrome, extracorporeal membrane oxygenation, left main coronary artery

DOI

Literature

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