Authors

• Klara Pospiš — Dubrava General Hospital, Zagreb, Croatia — ORCID: 0000-0002-4090-5512
• Ivan Zeljković — Dubrava General Hospital, Zagreb, Croatia — ORCID: 0000-0002-4550-4056
• Fran Šaler — Dubrava General Hospital, Zagreb, Croatia — ORCID: 0000-0002-1428-3940
• Marin Pavlov — Dubrava General Hospital, Zagreb, Croatia — ORCID: 0000-0003-3962-2774
• Jasmina Ćatić — Dubrava General Hospital, Zagreb, Croatia — ORCID: 0000-0001-6582-4201
• Šime Manola — Dubrava General Hospital, Zagreb, Croatia — ORCID: 0000-0001-6444-2674
• Ivana Jurin — Dubrava General Hospital, Zagreb, Croatia — ORCID: 0000-0002-2637-9691

Keywords

triglyceride-glucose index, acute myocardial infarction

DOI

Full Text

**Introduction**: In patients with acute myocardial infarction (AMI), the triglyceride-glucose (TyG) index may be a good predictor of adverse cardiac events. Higher TyG index has been linked to greater incidence of in-stent restenosis during percutaneous coronary intervention and severity of coronary artery disease, according to recent research. (1) Aim: To investigate the prognostic value of TyG index in patients with AMI. **Patients and Methods**: This was a registry-based study conducted at Dubrava University Hospital. We recruited patients with an AMI diagnosis from December 2016 to August 2023. The TyG index was calculated as ln[fasting triglyceride level (mg/dL)xfasting plasma glucose level (mg/dL)/2]. We collected data on gender, age, type of AMI: ST-elevation (STEMI) or non-ST-elevation (NSTE), occurrence of death from all causes, which was divided into several groups (death from: unknown or external causes, AMI, stroke, bleeding and pulmonary embolism). The primary outcomes were all-causes mortality and mortality from AMI during follow-up period. We looked into the relationships between the TyG index and the primary endpoints using the chi-square test. P value of 0.05 was defined as statistically significant. **Results**: We included 2273 patients diagnosed with AMI. Their median age was 64 years (IQR 56-73). Median follow-up was 18.6 months (IQR 2.4-42.5). The patients were split apart using the median of TyG index (4.126 mg/L) IQR (3.929-4.359). Statistically significant difference (chi-square 6.52, p=0.01) was observed in the deaths of 367 patients (16.1%) who were in the group with a higher TyG index. Patients with a TyG index above the median showed a statistically significant difference when evaluating mortality from AMI (chi-square 4.6781, p= 0.031). **Conclusion**: Among patients who experienced AMI, the TyG index was substantially correlated with both long-term all-cause death and death from AMI. TyG index may therefore be useful in daily clinical practice.

Literature

1. Zeng D, Wang K, Chen Z, Yao C. Association between TyG index and long-term prognosis of patients with ST-segment elevated myocardial infarction undergoing percutaneous coronary intervention: a retrospective cohort study. BMJ Open. 2024 June 17;14(6):e079279. https://doi.org/10.1136/bmjopen-2023-079279