Transplantation of cardiovascular tissue from University Hospital Centre Zagreb tissue banks

    Authors

    Keywords

    cardiovascular tissue, tissue bank, homograft

    DOI

    https://doi.org/10.15836/ccar2024.46

    Full Text

    The aim of the cardiovascular tissue bank is to store homografts - human tissue transplants of heart valves and blood vessels. (1) Transplantation of tissues or organs is seriously limited by the problems of lack of donors and immune rejection at the donor-recipient level. The development of tissue engineering enables tissue transplantation as well as cells from the patient’s own tissue. Therapy or treatment with tissue transplantation has been used for more than 50 years; however, one of its disadvantages is the possibility of disease transmission from the donor to the recipient. This risk is greatly reduced by excluding donors who are at risk of transmitting infection and by testing donors for transmissible infectious diseases. (2) Aseptic surgical technique in a quality environment, when extracting tissue from a donor, processing and storing tissue, and during implantation, is of key importance for preventing bacterial and fungal contamination. (3) Over the past two decades, the risk of disease transmission associated with tissue transplantation has been greatly reduced by the application of standards that are established by the professional organizations Association of Tissue Banks, European Association of Tissue Banks (EATB), and American Association of Eye Banks. (4) In the Republic of Croatia, the cardiovascular tissue bank took over the process technology of the largest European cardiovascular tissue bank, the European Homograft Bank from Brussels.

    Literature

    1. O’Brien MF, Harrocks S, Stafford EG, Gardner MA, Pohlner PG, Tesar PJ, et al. The homograft aortic valve: a 29-year, 99.3% follow up of 1,022 valve replacements. J Heart Valve Dis. 2001 May;10(3):334–44. https://pubmed.ncbi.nlm.nih.gov/11380096/
    2. Kim JY, Kim JB, Jung SH, Choo SJ, Chung CH, Lee JW. Long-Term Outcomes of Homografts in the Aortic Valve and Root Position: A 20-Year Experience. Korean J Thorac Cardiovasc Surg. 2016 August;49(4):258–63. 10.5090%2Fkjtcs.2016.49.4.258. https://doi.org/10.5090/kjtcs.2016.49.4.258
    3. Park S, Hwang HY, Kim KH, Kim KB, Ahn H. Midterm Follow-up after Cryopreserved Homograft Replacement in the Aortic Position. Korean J Thorac Cardiovasc Surg. 2012 February;45(1):30–4. https://doi.org/10.5090/kjtcs.2012.45.1.30
    4. Preventza O, Mohamed AS, Cooley DA, Rodriguez V, Bakaeen FG, Cornwell LD, et al. Homograft use in reoperative aortic root and proximal aortic surgery for endocarditis: A 12-year experience in high-risk patients. J Thorac Cardiovasc Surg. 2014 September;148(3):989–94. https://doi.org/10.1016/j.jtcvs.2014.06.025
    Cardiologia Croatica
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    Transplantation of cardiovascular tissue from University Hospital Centre Zagreb tissue banks

    Extended Abstract
    Issue1-2
    Published
    Pages46
    PDF via DOIhttps://doi.org/10.15836/ccar2024.46
    cardiovascular tissue
    tissue bank
    homograft

    Authors

    Renata Habeković*ORCIDUniversity Hospital Centre Zagreb, Zagreb, Croatia
    Mirjana DubravecORCIDUniversity Hospital Centre Zagreb, Zagreb, Croatia
    Danijela ŽigrovićORCIDUniversity Hospital Centre Zagreb, Zagreb, Croatia
    Sanjica Kurtanjek GorupecORCIDUniversity Hospital Centre Zagreb, Zagreb, Croatia

    *Correspondence email: rhabekov@kbc-zagreb.hr

    Full Text

    The aim of the cardiovascular tissue bank is to store homografts - human tissue transplants of heart valves and blood vessels. (1) Transplantation of tissues or organs is seriously limited by the problems of lack of donors and immune rejection at the donor-recipient level. The development of tissue engineering enables tissue transplantation as well as cells from the patient’s own tissue. Therapy or treatment with tissue transplantation has been used for more than 50 years; however, one of its disadvantages is the possibility of disease transmission from the donor to the recipient. This risk is greatly reduced by excluding donors who are at risk of transmitting infection and by testing donors for transmissible infectious diseases. (2) Aseptic surgical technique in a quality environment, when extracting tissue from a donor, processing and storing tissue, and during implantation, is of key importance for preventing bacterial and fungal contamination. (3) Over the past two decades, the risk of disease transmission associated with tissue transplantation has been greatly reduced by the application of standards that are established by the professional organizations Association of Tissue Banks, European Association of Tissue Banks (EATB), and American Association of Eye Banks. (4) In the Republic of Croatia, the cardiovascular tissue bank took over the process technology of the largest European cardiovascular tissue bank, the European Homograft Bank from Brussels.

    Literature

    1. 1.
      O’Brien MF, Harrocks S, Stafford EG, Gardner MA, Pohlner PG, Tesar PJ, et al. The homograft aortic valve: a 29-year, 99.3% follow up of 1,022 valve replacements. J Heart Valve Dis. 2001 May;10(3):334–44.PubMed
    2. 2.
      Kim JY, Kim JB, Jung SH, Choo SJ, Chung CH, Lee JW. Long-Term Outcomes of Homografts in the Aortic Valve and Root Position: A 20-Year Experience. Korean J Thorac Cardiovasc Surg. 2016 August;49(4):258–63. 10.5090%2Fkjtcs.2016.49.4.258.DOI
    3. 3.
      Park S, Hwang HY, Kim KH, Kim KB, Ahn H. Midterm Follow-up after Cryopreserved Homograft Replacement in the Aortic Position. Korean J Thorac Cardiovasc Surg. 2012 February;45(1):30–4.DOI
    4. 4.
      Preventza O, Mohamed AS, Cooley DA, Rodriguez V, Bakaeen FG, Cornwell LD, et al. Homograft use in reoperative aortic root and proximal aortic surgery for endocarditis: A 12-year experience in high-risk patients. J Thorac Cardiovasc Surg. 2014 September;148(3):989–94.DOI