Authors

• Dora Fabijanovic — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0003-2633-3439
• Ivo Planinc — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0003-0561-6704
• Jana Ljubas Macek — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0001-7171-2206
• Boško Skoric — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0001-5979-2346
• Zeljko Baricevic — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0002-5420-2324
• Hrvoje Jurin — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0002-2599-553X
• Jure Samardzic — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0002-9346-6402
• Hrvoje Gašparovic — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0002-2492-3702
• Maja Cikeš — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0002-4772-5549
• Davor Milicic — University of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0001-9101-1570

Abstract

Goal: The clinical value of cardiac biomarkers (such as brain natriuretic peptide (BNP) or troponin T) in heart transplant (HTx) recipients is not completely defined. Despite multiple published studies on the association between cardiac biomarkers and survival or acute allograft rejection, there is insufficient evidence to recommend them in everyday clinical practice. (1, 2) We sought to explore survival of patients after HTx in relation to NTpro-BNP and high sensitive TnT (hs-TnT) values throughout the 1st post-HTx year in our center. Patients and Methods: In this retrospective observational study we included 74 consecutive HTx recipients (53 male, median follow-up 24 months) in whom we obtained NTpro-BNP (pg/mL) and hs-TnT (pg/L) values at 1, 6 and 12 months after HTx. For each time point, we used the median of measurements as a cut-off value for further analysis. Survival rates were analysed by the Kaplan-Meier method (log rank test), followed by the univariate Cox hazard regression analysis. Results: Cut-off median values for respective measurements at specific time points were as follows: NTpro-BNP 1967.5, 418.7 and 366.8 pg/mL; hs-TnT 90, 18.5 and 16 pg/L at 1, 6 and 12 months after HTx, respectively. The patients with lower hs-TnT values at 12-months after HTx had significantly better survival rates (p = 0.048) (**Figure 1**), with a HR of 1.014 (95% CI 1.003-1.024 p = 0.01). Although NTpro-BNP and hs-TnT values at the earlier time points showed a trend towards better survival in patients with lower biomarker values, statistical significance was not observed. Figure 1. Cumulative survival based on hs-TnT levels 12 months post-Htx. Conclusion: The results of our study suggest the importance of biomarker measurements (particularly hs-TnT), even in the later post-transplant period. Larger study groups might enforce its role in detecting individuals at higher risk for worse outcomes.

Keywords

heart transplantation, high sensitive troponin, brain natriuretic peptide

DOI

Literature

1. Erbel C, Taskin R, Doesch A, Dengler TJ, Wangler S, Akhavanpoor M, et al. High-sensitive Troponin T measurements early after heart transplantation predict short- and long-term survival. Transpl Int. 2013;26(3):267–72. https://doi.org/10.1111/tri.12024
2. Battes LC, Caliskan K, Rizopoulos D, Constantinescu AA, Robertus JL, Akkerhuis M, et al. Repeated measurements of NT-pro-B-type natriuretic peptide, troponin T or C-reactive protein do not predict future allograft rejection in heart transplant recipients. Transplantation. 2015;99(3):580–5. https://doi.org/10.1097/TP.0000000000000378