Authors

• Dominik Buljan — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0001-9603-2610
• Anđela Jurišić — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0001-8316-4294
• Marin Viđak — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0003-0341-9598
• Tomo Svaguša — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0002-2036-1239
• Diana Rudan — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0001-9473-2517
• Ante Lisičić — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0002-4365-9652
• Tomislav Šipić — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0001-8652-4523
• Aleksandar Blivajs — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0003-3404-3837
• Vanja Ivanović Mihajlović — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0001-6931-5404
• Ivan Zeljković — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0002-4550-4056
• Šime Manola — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0001-6444-2674
• Ivana Jurin — Dubrava University Hospital, Zagreb, Croatia — ORCID: 0000-0002-2637-9691

Keywords

inflammatiory markers, C-reactive protein, acute coronary sindrome, cardiovascular ischemic events

DOI

Full Text

**Introduction**: The role of inflammation is known in genesis of atherosclerosis and consequently atherosclerotic cardiovascular disease (ASCVD) events. Data from previous research exposed significant relation between elevated plasma level of C-reactive protein (CRP) and prevalence of underlying atherosclerosis as well as risk of recurent adverse cardiovascular events among patients with established ASCVD. Furthermore, some studies showed connection between increased plasma concentration of other inflammatory markers like fibrinogen, IL-1β, SDF-1α and cardiovascular ischemic events. (1, 2) The primary aim of this study is to examine relation of early CRP values and all-cause mortality among patients with acute coronary sindrome (ACS). **Patients and Methods**: This single-center registry-based prospective research included 2536 patients with acute coronary sindrome who were hospitalized between January 2017 and December 2023 and had long-term follow up. Early CRP values were evaluated at admission to the hospital. The primary composite end point was all-cause mortality, contained of cardiovascular and non-cardiovascular mortality. Secondary analyzed outcome was reinfarction. All the participants were exposed to percutaneous coronary intervention. Patients with proven infection were excluded. **Results:** A total of 462 patients (18.2%) died during the long-term follow up. Early CRP values were mesured among 409 of them (88.5%); 289 (70.7%) of whom died due to cardiovascular death and 134 (29.3%) of whom died due to non-cardiovascular death. This study showed no significant difference in observed values of CRP between mortality groups (7.2 vs 7.0, p=0.825). **Conclusion**: While some previous studies showed significant difference for risk-prediction following ACS due to early mesured CRP values, this observational study showed no significant difference in observed CRP values between mortality groups. Furthermore, there are other inflammatory markers which should be messured at the admission to the hospital and compared among tested groups.

Literature

1. Alkouri A, Cybularz M, Mierke J, Nowack T, Biedermann J, Ulbrich S, et al. The predictive role of early CRP values for one-year mortality in the first 2 d after acute myocardial infarction. Biomarkers. 2022 May;27(3):293–8. https://doi.org/10.1080/1354750X.2022.2040591
2. Oprescu N, Micheu MM, Scafa-Udriste A, Popa-Fotea NM, Dorobantu M. Inflammatory markers in acute myocardial infarction and the correlation with the severity of coronary heart disease. Ann Med. 2021 December;53(1):1041–7. https://doi.org/10.1080/07853890.2021.1916070