The influence of anthropometric factors on the concentration of resistin levels in patients with hemodynamically significant carotid artery stenosis

    Authors

    Keywords

    resistin, atherosclerosis, waist circumference, carotid stenosis

    DOI

    https://doi.org/10.15836/ccar2016.514

    Full Text

    **Introduction:** The most important pathophysiological mechanism of development of carotid atherosclerotic disease is an inflammatory process. With the aim of better understanding of the process, numerous biomarkers were studied including resistin. Resistin peptide intensifies development of atherosclerosis by stimulating monocytes, endothelial cells and smooth muscle cells in the development of inflammation of the vascular endothelium. (1) Aim: Connection between resistin with insulin resistance, obesity and diabetes is well known. Here we present the results of subanalysis research of the relationship between resistin and histology of an atherosclerotic carotid plaque with emphasis on the impact of anthropometric factors (age, sex, body height, body weight and waist circumference) on the serum concentration of resistin. **Patients and Methods:** The study included 78 patients (30 women) with significant carotid artery stenosis which were planned for elective endarterectomy. Before the surgery concentration in serum resistin (1967.15-18619.73, mean 7552.3162 pg/ml) were measured and anthropometric data were determined as follows: age (45-84; mean age, 66.83 years), body height (148 to 187; mean height 168.78 cm), body weight (47-110, average weight 80.49 kg), and waist circumference (75-122, midrange 101.27 cm). **Results:** Subanalysis of data showed statistically significant positive correlation between the concentration of resistin with waist circumference (p = 0.003) and male gender (p = 0.008). **Conclusion:** These results indicate a clear connection between the classic risk factors for atherosclerosis and relatively new inflammatory marker resistin. Further research is needed to confirm the possibility of using resistin as a marker of atherosclerotic disease.

    Literature

    1. Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A, et al. Correlation between serum resisting level and adiposity in obese individuals. Obes Res. 2003;11:997–1001. https://doi.org/10.1038/oby.2003.137
    Cardiologia Croatica
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    The influence of anthropometric factors on the concentration of resistin levels in patients with hemodynamically significant carotid artery stenosis

    Extended Abstract
    Issue10-11
    Published
    Pages514
    PDF via DOIhttps://doi.org/10.15836/ccar2016.514
    resistin
    atherosclerosis
    waist circumference
    carotid stenosis

    Authors

    Ivana Jurin*ORCIDUniversity Hospital Dubrava, Zagreb, Croatia
    Marko AjdukUniversity Hospital Dubrava, Zagreb, Croatia
    Lovorka ĐerekORCIDUniversity Hospital Dubrava, Zagreb, Croatia
    Marijan PašalićUniversity of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb,Croatia
    Diana RudanUniversity Hospital Dubrava, Zagreb, Croatia
    Sanda SokolUniversity Hospital Dubrava, Zagreb, Croatia
    TomićORCIDUniversity Hospital Dubrava, Zagreb, Croatia
    Stela BulimbašićUniversity of Zagreb School of Medicine, University Hospital Centre Zagreb, Zagreb,Croatia

    *Correspondence email: ivana.sakic@yahoo.com

    Full Text

    Introduction: The most important pathophysiological mechanism of development of carotid atherosclerotic disease is an inflammatory process. With the aim of better understanding of the process, numerous biomarkers were studied including resistin. Resistin peptide intensifies development of atherosclerosis by stimulating monocytes, endothelial cells and smooth muscle cells in the development of inflammation of the vascular endothelium. (1) Aim: Connection between resistin with insulin resistance, obesity and diabetes is well known. Here we present the results of subanalysis research of the relationship between resistin and histology of an atherosclerotic carotid plaque with emphasis on the impact of anthropometric factors (age, sex, body height, body weight and waist circumference) on the serum concentration of resistin.

    Patients and Methods: The study included 78 patients (30 women) with significant carotid artery stenosis which were planned for elective endarterectomy. Before the surgery concentration in serum resistin (1967.15-18619.73, mean 7552.3162 pg/ml) were measured and anthropometric data were determined as follows: age (45-84; mean age, 66.83 years), body height (148 to 187; mean height 168.78 cm), body weight (47-110, average weight 80.49 kg), and waist circumference (75-122, midrange 101.27 cm).

    Results: Subanalysis of data showed statistically significant positive correlation between the concentration of resistin with waist circumference (p = 0.003) and male gender (p = 0.008).

    Conclusion: These results indicate a clear connection between the classic risk factors for atherosclerosis and relatively new inflammatory marker resistin. Further research is needed to confirm the possibility of using resistin as a marker of atherosclerotic disease.

    Literature

    1. 1.
      Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A, et al. Correlation between serum resisting level and adiposity in obese individuals. Obes Res. 2003;11:997–1001.DOI