Systemic thrombolytic therapy in patients with intermediate-high-risk pulmonary embolism

    Authors

    Keywords

    pulmonary embolism, thrombolytic therapy

    DOI

    https://doi.org/10.15836/ccar2022.292

    Full Text

    Pulmonary embolism remains the one of the commonest cardiovascular disease, the severity of which is variable and can be lethal. The incidence is expected to increase due to the aging population. Intermediate-high risk pulmonary embolism is characterized by hemodynamical stability, but elevated mortality risk and both radiographic and laboratory signs of right heart strain. Thrombolysis remains a possible life saving treatment option but bears an increased risk of potentially life-threatening hemorrhage. Optimal treatment is still not established. ( 1 - 3 ) We present a series of intermediate-high risk patients treated in our hospital with thrombolytic therapy (n=4, 2 male, median age 58.5) and compare relevant direct and indirect values of right ventricular load before and after treatment ( Table 1 ). We also provide a summary of our clinical approach in light of current guidelines and two meta-analyses.

    Cardiologia Croatica
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    Systemic thrombolytic therapy in patients with intermediate-high-risk pulmonary embolism

    Extended Abstract
    Issue9-10
    Published
    Pages292
    PDF via DOIhttps://doi.org/10.15836/ccar2022.292
    pulmonary embolism
    thrombolytic therapy

    Authors

    Karlo Golubić*ORCIDSestre Milosrdnice University Hospital Centre, Zagreb, Croatia
    Nikola KosORCIDSestre Milosrdnice University Hospital Centre, Zagreb, Croatia
    Tonći BatinićORCIDSestre Milosrdnice University Hospital Centre, Zagreb, Croatia
    Mislav VrsalovićORCIDSestre Milosrdnice University Hospital Centre, Zagreb, Croatia

    Full Text

    Pulmonary embolism remains the one of the commonest cardiovascular disease, the severity of which is variable and can be lethal. The incidence is expected to increase due to the aging population. Intermediate-high risk pulmonary embolism is characterized by hemodynamical stability, but elevated mortality risk and both radiographic and laboratory signs of right heart strain. Thrombolysis remains a possible life saving treatment option but bears an increased risk of potentially life-threatening hemorrhage. Optimal treatment is still not established. ( 1 - 3 ) We present a series of intermediate-high risk patients treated in our hospital with thrombolytic therapy (n=4, 2 male, median age 58.5) and compare relevant direct and indirect values of right ventricular load before and after treatment ( Table 1 ). We also provide a summary of our clinical approach in light of current guidelines and two meta-analyses.