Significant improvement of systolic function after pulmonary vein isolation by cryoablation – a case report

    Authors

    Keywords

    atrial fibrillation, cryoablation, heart failure, pulmonary vein isolation

    DOI

    https://doi.org/10.15836/ccar2021.16

    Full Text

    Introduction : Atrial fibrillation can lead to heart failure with reduced ejection fraction (HFrEF) by reducing cardiac output due to irregular rhythm, high frequency of the ventricles, reducing diastole time and loss of atrial contraction. HFrEF could also potentiate the onset of atrial fibrillation due to the increase of pressure in the left atrium, enlargement of the left atrium, activation of the sympathetic nervous system which in turn can potentiate automatic triggers and functional mitral regurgitation. ( 1 ) Case report : We present 47-year old male who was physically active, playing amateur football. On routine check-ups persistent normofrequent atrial fibrillation was found along with dilation of all four chambers. Patient complained of exertion fatigue, dyspnea on exertion and feeling of an irregular heart rhythm. Transthoracic echocardiography revealed diffuse hypocontractility and severe reduction in systolic function of the left ventricle, with ejection fraction (EF) of 35%. Coronary artery disease was excluded. Automatic cardioverter defibrillator (AICD) was implanted in primary prevention of sudden cardiac death. Two and a half years later systolic function has improved (EF 50%) and there was a spontaneous conversion to sinus rhythm. AICD was explanted on patient request. Less than a year after, systolic function has once again declined (EF 20%) and a recurrence of persistent atrial fibrillation with average heart rate obtained in Holter ECG 90/min was observed. After the recurrence of arrhythmia post electrocardioversion, pulmonary vein isolation with cryoablation was performed. Eight and 17 months after the ablation no recurrence of atrial fibrillation was found. Patient is again physically active (jogging) and ejection fraction returned to normal. Conclusion : Atrial fibrillation and heart failure with their pathophysiological mechanisms can make the “circulus vitiosus”. This case report shows how removal of arrhythmogenic triggers, normalization of the heart rhythm and heart rate could significantly contribute to the improvement of heart function. That could be explained by halting, and possibly even reverting, the structural and electrical heart remodeling.

    Cardiologia Croatica
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    Significant improvement of systolic function after pulmonary vein isolation by cryoablation – a case report

    Extended Abstract
    Issue1-2
    Published
    Pages16
    PDF via DOIhttps://doi.org/10.15836/ccar2021.16
    atrial fibrillation
    cryoablation
    heart failure
    pulmonary vein isolation

    Authors

    Barbara Rubinić*ORCIDUniversity of Zagreb School of Medicine, Zagreb, Croatia
    Mia DubravčićORCIDUniversity of Zagreb School of Medicine, Zagreb, Croatia
    Hrvoje JurinORCIDUniversity of Zagreb School of Medicine, Zagreb, Croatia
    Daniel LovrićORCIDUniversity of Zagreb School of Medicine, Zagreb, Croatia
    Borka Pezo-NikolićORCIDUniversity of Zagreb School of Medicine, Zagreb, Croatia
    Mislav PuljevićORCIDUniversity of Zagreb School of Medicine, Zagreb, Croatia
    Vedran VelagićORCIDUniversity of Zagreb School of Medicine, Zagreb, Croatia
    Davor PuljevićORCIDUniversity of Zagreb School of Medicine, Zagreb, Croatia

    Full Text

    Introduction : Atrial fibrillation can lead to heart failure with reduced ejection fraction (HFrEF) by reducing cardiac output due to irregular rhythm, high frequency of the ventricles, reducing diastole time and loss of atrial contraction. HFrEF could also potentiate the onset of atrial fibrillation due to the increase of pressure in the left atrium, enlargement of the left atrium, activation of the sympathetic nervous system which in turn can potentiate automatic triggers and functional mitral regurgitation. ( 1 ) Case report : We present 47-year old male who was physically active, playing amateur football. On routine check-ups persistent normofrequent atrial fibrillation was found along with dilation of all four chambers. Patient complained of exertion fatigue, dyspnea on exertion and feeling of an irregular heart rhythm. Transthoracic echocardiography revealed diffuse hypocontractility and severe reduction in systolic function of the left ventricle, with ejection fraction (EF) of 35%. Coronary artery disease was excluded. Automatic cardioverter defibrillator (AICD) was implanted in primary prevention of sudden cardiac death. Two and a half years later systolic function has improved (EF 50%) and there was a spontaneous conversion to sinus rhythm. AICD was explanted on patient request. Less than a year after, systolic function has once again declined (EF 20%) and a recurrence of persistent atrial fibrillation with average heart rate obtained in Holter ECG 90/min was observed. After the recurrence of arrhythmia post electrocardioversion, pulmonary vein isolation with cryoablation was performed. Eight and 17 months after the ablation no recurrence of atrial fibrillation was found. Patient is again physically active (jogging) and ejection fraction returned to normal. Conclusion : Atrial fibrillation and heart failure with their pathophysiological mechanisms can make the “circulus vitiosus”. This case report shows how removal of arrhythmogenic triggers, normalization of the heart rhythm and heart rate could significantly contribute to the improvement of heart function. That could be explained by halting, and possibly even reverting, the structural and electrical heart remodeling.