Authors

• Filipa Grljušić — General Hospital “Dr. Josip Benčević” Slavonski Brod, Slavonski Brod, Croatia — ORCID: 0009-0009-8221-0549
• Vlatka Rešković Lukšić — University of Zagreb, School of Medicine, Zagreb, Croatia — ORCID: 0000-0002-4721-3236
• Blanka Glavaš Konja — University of Zagreb, School of Medicine, Zagreb, Croatia — ORCID: 0000-0003-1134-4856
• Jadranka Šeparović Hanževački — University of Zagreb, School of Medicine, Zagreb, Croatia — ORCID: 0000-0002-3437-6407
• Marija Brestovac — University of Zagreb, School of Medicine, Zagreb, Croatia — ORCID: 0000-0003-1542-2890
• Sandra Jakšić Jurinjak — University of Zagreb, School of Medicine, Zagreb, Croatia — ORCID: 0000-0002-7349-6137

Keywords

pericardial effusion, electrocardioversion, dabigatran, amiodarone, pericarditis

DOI

Full Text

**Introduction:** Pericardial effusion is an abnormal amount of pericardial fluid for various reasons. When it accumulates slowly, there can be a large pericardial effusion without cardiac tamponade. (1) In most cases, atrial arrhythmias require antiarrhythmics, electrocardioversion, and catheter ablation to restore and sustain sinus rhythm, in addition to anticoagulant therapy to prevent thromboembolic incidents. (2) Occasionally, these treatments can contribute to the development of pericardial effusion. (2, 3) **Case report:** 62-year-old female patient presented with shortness of breath following minimal effort a month and a half ago. She had a past medical history of paroxysmal atrial flutter with successful direct-current electrical cardioversion 2 months ago. She was prescribed oral amiodarone 100 mg once daily and dabigatran 150 mg twice daily. She was hemodynamically stable on admission. The ECG showed sinus rhythm with diffuse microvoltage. Laboratory tests revealed mild normocytic anemia, hypoproteinemia, and slightly elevated inflammatory markers. Echocardiography revealed a large pericardial effusion with fibrin deposits measuring up to 50 mm next to the right atrium and ventricle in the subcostal view, while other findings were normal (**Figure 1**). Further investigations showed erosive gastritis, right carotid artery stenosis, significant stenosis of the brachiocephalic trunk and left subclavian artery, as well as an infrarenal abdominal aortic aneurysm. Upon admission, dabigatran and amiodarone were discontinued. The patient was treated with ibuprofen, colchicine and gastroprotection. This was accompanied by a recovery from anemia, normalization of inflammatory markers, and a significant reduction in pericardial effusion, which measured 11 mm on the 14th day of hospitalization (**Figure 2**). Subsequently, immunological results revealed a positive finding of OJ antibodies. Two weeks later, the pericardial effusion had resolved (**Figure 3**), and a PET/CT scan demonstrated increased radiopharmaceutical accumulation in the aortic walls, both subclavian arteries, and both hilus with enlarged lymph nodes and small nodular lung lesions. FIGURE 1. The subcostal view shows a significant pericardial effusion. FIGURE 2. By the 14th day of hospitalization, there was a significant decrease in pericardial effusion observed in both the long parasternal view (left) and the subcostal view (right). FIGURE 3. The subcostal view (left) and 4-chamber view (right) demonstrate the resolution of pericardial effusion following four weeks of conservative treatment. **Conclusion:** This is a case of reactive pericarditis accompanied by pericardial effusion, influenced by several potential precipitating factors: anticoagulant therapy combined with amiodarone, electrocardioversion, and the possibility of an underlying (systemic) disease. It is important to highlight the favorable and rapid response to a conservative treatment approach for extensive pericardial effusion.

Literature

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