Outcomes in patients with heart failure with regard to statin therapy

    Authors

    Abstract

    **Objective**: The aim of this study was to investigate whether statin therapy influenced outcomes in patients with acute heart failure (HF). (1, 2) **Patients and Methods**: Eighty five patients with diagnosis of HF were included in the study. For each patient the following data were obtained: gender, age, comorbidities and medications. New York Heart association (NYHA) class for heart failure was determined by physician evaluation and left ventricle ejection fraction (LVEF) was determined by echocardiography. Outcome points were: hospitalization, in-hospital death, mortality after 6 months, 1 year and 2 years. All-cause mortality included cardiovascular events or worsening heart failure. **Results**: Mortality after 6 months, 1 year and 2 years was the most frequent in patients without statin therapy with a statistically significant difference (p = 0.001). Progression of HF accounted for 31.7% of mortality in patients without statin therapy. **Conclusion**: Statin therapy is associated with substantially better long-term outcomes in patients with HF.

    DOI

    https://doi.org/10.15836/ccar2019.222

    Literature

    1. Alehagen U, Benson L, Edner M, Dahlström U, Lund LH. Association between use of statins and outcomes in heart failure with reduced ejection fraction: prospective propensity score matched cohort study of 21 864 patients in the Swedish Heart Failure Registry. Circ Heart Fail. 2015 Mar;8(2):252–60. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001730
    2. Preiss D, Campbell RT, Murray HM, Ford I, Packard CJ, Sattar N, et al. The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials. Eur Heart J. 2015 Jun 21;36(24):1536–46. https://doi.org/10.1093/eurheartj/ehv072
    Cardiologia Croatica
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    Outcomes in patients with heart failure with regard to statin therapy

    Extended Abstract
    Issue9-10
    Published
    Pages222
    PDF via DOIhttps://doi.org/10.15836/ccar2019.222

    Authors

    Amina Godinjak*ORCIDEurofarm Centar Medical Clinic, Sarajevo, Bosnia and Herzegovina
    Miralem ĐeševićORCIDEurofarm Centar Medical Clinic, Sarajevo, Bosnia and Herzegovina
    Amer IglicaORCIDClinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
    Adis KukuljacORCIDGeneral Hospital Sarajevo, Sarajevo, Bosnia and HerzegovinaKEYWORDS: heart failure, statin therapy, outcome.

    *Correspondence email: aminagodinjak@gmail.com

    Abstract

    **Objective**: The aim of this study was to investigate whether statin therapy influenced outcomes in patients with acute heart failure (HF). (1, 2) **Patients and Methods**: Eighty five patients with diagnosis of HF were included in the study. For each patient the following data were obtained: gender, age, comorbidities and medications. New York Heart association (NYHA) class for heart failure was determined by physician evaluation and left ventricle ejection fraction (LVEF) was determined by echocardiography. Outcome points were: hospitalization, in-hospital death, mortality after 6 months, 1 year and 2 years. All-cause mortality included cardiovascular events or worsening heart failure. **Results**: Mortality after 6 months, 1 year and 2 years was the most frequent in patients without statin therapy with a statistically significant difference (p = 0.001). Progression of HF accounted for 31.7% of mortality in patients without statin therapy. **Conclusion**: Statin therapy is associated with substantially better long-term outcomes in patients with HF.

    Literature

    1. 1.
      Alehagen U, Benson L, Edner M, Dahlström U, Lund LH. Association between use of statins and outcomes in heart failure with reduced ejection fraction: prospective propensity score matched cohort study of 21 864 patients in the Swedish Heart Failure Registry. Circ Heart Fail. 2015 Mar;8(2):252–60.DOI
    2. 2.
      Preiss D, Campbell RT, Murray HM, Ford I, Packard CJ, Sattar N, et al. The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials. Eur Heart J. 2015 Jun 21;36(24):1536–46.DOI