Optimal medicamentous therapy for patients with severe mitral regurgitation

    Authors

    Keywords

    mitral regurgitation, medications, left ventricle function

    DOI

    https://doi.org/10.15836/ccar2018.191

    Full Text

    Background: Mitral regurgitation (MR) represents the second most common valvular heart disease. It is classified as primary (organic) and secondary (functional) MR, with secondary being more frequent. Degenerative vavular disease, rheumatic fever, infective endocarditis and mitral valve prolapse are most common causes of primary MR. On the other hand, secondary MR is usually result of ischaemic heart disease or dilatative cardiomyopathy. Furthermore, according to haemodynamic echocardiographic parameters MR is classiffied as mild, moderate and severe ( 1 ). Treatment modalities include surgery and medications. Mitral valve repair and replacement represents the way of treating symptomatic severe MR, while medications have a role to prevent or slowing down the progression of mitral valve cusps degeneration and left ventricular remodelation ( 1 ). Discussion: Among medications, beta-blockers, angiotensin converting enzyme inhibitors, aldosterone antagonists, calcium channel blockers are widely used for treating patients who are symptomatic, have decreased left ventricle systolic function and waiting for surgery or have contraindication for surgery ( 2 ). It has been showed that beta-blockers reduce MR, prevent further deterioration of left ventricular systolic function in patients with primary MR 2 . Beta-blockers improve left ventricular function in chronic degenerative mitral regurgitation. Also, they improve NYHA functional class and left ventricular volumes in those with rheumatic mitral valve disease ( 3 ). Angiotensine converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs) reduces regurgitant volume and left ventricular size, mass and volumes in patients with primary MR 2 . Renin-angiotensin system inhibitors improve survival rate in patients with secondary MR due to ischaemic heart disease ( 3 ). Nitrates reduce left ventricular end diastolic and systolic volumes thereby reducing ventricular dilatation, while calcium channel blockers reduce regurgitant volume ( 2 ). Conclusion: Optimal medication prevents left ventricular function worsening, improves NYHA functional class and survival rate. All above mentioned recommentadions are based on small studies, different patient populations, patients using other cardioactive drugs, so further investigations should be done.

    Cardiologia Croatica
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    Optimal medicamentous therapy for patients with severe mitral regurgitation

    Extended Abstract
    Issue5-6
    Published
    Pages191
    PDF via DOIhttps://doi.org/10.15836/ccar2018.191
    mitral regurgitation
    medications
    left ventricle function

    Authors

    Edvard Galić*ORCIDUniversity Hospital “Sveti Duh”, Zagreb, Croatia
    Vera SlatinskiORCIDUniversity Hospital “Sveti Duh”, Zagreb, Croatia
    Ante PašalićORCIDUniversity Hospital “Sveti Duh”, Zagreb, Croatia
    Marko PerčićORCIDUniversity Hospital “Sveti Duh”, Zagreb, Croatia
    Zrinka PlaninićORCIDUniversity Hospital “Sveti Duh”, Zagreb, Croatia

    Full Text

    Background: Mitral regurgitation (MR) represents the second most common valvular heart disease. It is classified as primary (organic) and secondary (functional) MR, with secondary being more frequent. Degenerative vavular disease, rheumatic fever, infective endocarditis and mitral valve prolapse are most common causes of primary MR. On the other hand, secondary MR is usually result of ischaemic heart disease or dilatative cardiomyopathy. Furthermore, according to haemodynamic echocardiographic parameters MR is classiffied as mild, moderate and severe ( 1 ). Treatment modalities include surgery and medications. Mitral valve repair and replacement represents the way of treating symptomatic severe MR, while medications have a role to prevent or slowing down the progression of mitral valve cusps degeneration and left ventricular remodelation ( 1 ). Discussion: Among medications, beta-blockers, angiotensin converting enzyme inhibitors, aldosterone antagonists, calcium channel blockers are widely used for treating patients who are symptomatic, have decreased left ventricle systolic function and waiting for surgery or have contraindication for surgery ( 2 ). It has been showed that beta-blockers reduce MR, prevent further deterioration of left ventricular systolic function in patients with primary MR 2 . Beta-blockers improve left ventricular function in chronic degenerative mitral regurgitation. Also, they improve NYHA functional class and left ventricular volumes in those with rheumatic mitral valve disease ( 3 ). Angiotensine converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs) reduces regurgitant volume and left ventricular size, mass and volumes in patients with primary MR 2 . Renin-angiotensin system inhibitors improve survival rate in patients with secondary MR due to ischaemic heart disease ( 3 ). Nitrates reduce left ventricular end diastolic and systolic volumes thereby reducing ventricular dilatation, while calcium channel blockers reduce regurgitant volume ( 2 ). Conclusion: Optimal medication prevents left ventricular function worsening, improves NYHA functional class and survival rate. All above mentioned recommentadions are based on small studies, different patient populations, patients using other cardioactive drugs, so further investigations should be done.