Myocardial infarction as a consequence of polyartheritis nodosa diagnosed in childhood – case report

    Authors

    Keywords

    polyarteritis nodosa, myocardial infarction, young age

    DOI

    https://doi.org/10.15836/ccar2016.440

    Full Text

    Polyarteritis nodosa (PAN) is a systemic vasculitis histologically characterized by necrotic lesions of medium-sized and small arteries, mostly in their bifurcations. PAN is a multi-organ disorder that affects more visceral arteries and the consequences of inflammation and necrosis can lead to ischemia of vital organs. The etiology of the disease is unknown. There are four forms - cutaneous (which is most common), classic, and microscopic system. PAN preferably affects the renal and coronary arteries. The most common finding of affected blood vessels are aneurysm, thrombosis and stenosis. Cardiac complications are rare in children, but 35% of patients in adulthood is developing a complication. The most common complications in adulthood is cardiac decompensation and can be explained as a consequence of long-standing hypertension and changes in coronary blood vessels. The incidence of myocardial infarction is low, particularly in young patients. (1-3) This paper describes the 25-year-old patient with acute myocardial infarction with the changes in the coronary blood vessels and persistent arterial hypertension as a result of PAN diagnosed in childhood.

    Literature

    1. Jelušić M. Nodozni poliarteritis. In: Jelušić M, Malčić I, editors. Pedijatrijska reumatologija; Zagreb; Medicinska naklada; 2014. p. 252-256.
    2. Dillon MJ, Ozen S. Polyarteritis nodosa and cutaneous polyarteritis nodosa. In: Cassidy JT, Petty RE, Laxer RM,Lindsley CB, editors. Textbook of pediatric rheumatology, 6th edn; Philadelphia; WB Saunders company; 2011. p. 498—505.
    3. Malčić I, Jelušić M, Sršen-Krstulović M. Današnje poveznice pedijatrijske kardiologije i reumatologije od fetalne do odrasle dobi — sistemske bolesti vezivnog tkiva i srca u stalnom prožimanju. Paediatr Croat. 2014;58 Suppl 2:56–63.
    Cardiologia Croatica
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    Myocardial infarction as a consequence of polyartheritis nodosa diagnosed in childhood – case report

    Extended Abstract
    Issue10-11
    Published
    Pages440
    PDF via DOIhttps://doi.org/10.15836/ccar2016.440
    polyarteritis nodosa
    myocardial infarction
    young age

    Authors

    Viktorija Ana Buljević*ORCIDUniversity Hospital Center Zagreb, Zagreb, Croatia
    Matias TrbušićORCIDUniversity Hospital Center «Sestre milosrdnice», Zagreb, Croatia
    Ivan MalčićORCIDUniversity Hospital Center Zagreb, Zagreb, Croatia

    *Correspondence email: viktorija.ana.buljevic@gmail.com

    Full Text

    Polyarteritis nodosa (PAN) is a systemic vasculitis histologically characterized by necrotic lesions of medium-sized and small arteries, mostly in their bifurcations. PAN is a multi-organ disorder that affects more visceral arteries and the consequences of inflammation and necrosis can lead to ischemia of vital organs. The etiology of the disease is unknown. There are four forms - cutaneous (which is most common), classic, and microscopic system. PAN preferably affects the renal and coronary arteries. The most common finding of affected blood vessels are aneurysm, thrombosis and stenosis. Cardiac complications are rare in children, but 35% of patients in adulthood is developing a complication. The most common complications in adulthood is cardiac decompensation and can be explained as a consequence of long-standing hypertension and changes in coronary blood vessels. The incidence of myocardial infarction is low, particularly in young patients. (1–3)

    This paper describes the 25-year-old patient with acute myocardial infarction with the changes in the coronary blood vessels and persistent arterial hypertension as a result of PAN diagnosed in childhood.

    Literature

    1. 1.
      Jelušić M. Nodozni poliarteritis. In: Jelušić M, Malčić I, editors. Pedijatrijska reumatologija; Zagreb; Medicinska naklada; 2014. p. 252-256.
    2. 2.
      Dillon MJ, Ozen S. Polyarteritis nodosa and cutaneous polyarteritis nodosa. In: Cassidy JT, Petty RE, Laxer RM,Lindsley CB, editors. Textbook of pediatric rheumatology, 6th edn; Philadelphia; WB Saunders company; 2011. p. 498—505.
    3. 3.
      Malčić I, Jelušić M, Sršen-Krstulović M. Današnje poveznice pedijatrijske kardiologije i reumatologije od fetalne do odrasle dobi — sistemske bolesti vezivnog tkiva i srca u stalnom prožimanju. Paediatr Croat. 2014;58 Suppl 2:56–63.