Mechanical Thrombectomy in ST-segment Elevation Myocardial Infarction

    Authors

    Keywords

    mechanical thrombectomy, primary PCI, ST-segment elevation myocardial infarction

    DOI

    https://doi.org/10.15836/ccar2016.95

    Full Text

    **Introduction:** Occlusive thrombus due to ruptured or eroded atherosclerotic plaque is the most frequent substrate for ST-segment elevation myocardial infarction (STEMI). Distal embolization of intracoronary thrombus results in microvascular obstruction and compromised TIMI (Thrombolysis In Myocardial Infarction) flow. Forceful coronary injections, passage of intracoronary devices, initial balloon angioplasty and/or stenting induce distal embolization. Intracoronary thrombus additionally may contribute to vessel and stent undersizing increasing the risk of stent malapposition, in-stent restenosis or stent thrombosis. (1-3) **Case presentation:** We present an 81-year-old Caucasian male with STEMI with rapid progression to cardiogenic shock and cardiorespiratory arrest during diagnostic coronary angiography. Severe stenosis of right coronary artery (RCA) with occlusive thrombus of the left main (LM) was found. The patient received a veno-arterial extracorporeal membrane oxygenation (ECMO) device. We performed a standard percutaneous coronary intervention (PCI) of RCA and rheolytic thrombectomy (AngioJet™) of the LM. The patient was successfully weaned from ECMO 29 hours after the procedure, with no inoconstrictor support. After nine days he was fully mobilized with no neurological deficit and a 40% left ventricular ejection fraction on echocardiography. **Conclusion:** Current evidence does not support the routine use of rheolytic thrombectomy in primary PCI. In specific cases that are involving large occlusive thrombus it may be a therapy of choice.

    Literature

    1. Parodi G, Valenti R, Migliorini A, Maehara A, Vergara R, Carrabba N, et al. Comparison of manual thrombus aspiration with rheolytic thrombectomy in acute myocardial infarction. Circ Cardiovasc Interv. 2013;6(3):224–30. https://doi.org/10.1161/CIRCINTERVENTIONS.112.000172
    2. Beran G, Lang I, Schreiber W, Denk S, Stefenelli T, Syeda B, et al. Intracoronary thrombectomy with the X-sizer catheter system improves epicardial flow and accelerates ST-segment resolution in patients with acute coronary syndrome: a prospective, randomized, controlled study. Circulation. 2002;105:2355–60. https://doi.org/10.1161/01.CIR.0000016350.02669.1D
    3. Antoniucci D, Valenti R, Migliorini A, Parodi G, Memisha G, Santoro GM, et al. Comparison of rheolytic thrombectomy before direct infarct artery stenting versus direct stenting alone in patients undergoing percutaneous coronary intervention for acute myocardial infarction. Am J Cardiol. 2004;93:1033–5. https://doi.org/10.1016/j.amjcard.2004.01.011
    Cardiologia Croatica
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    Mechanical Thrombectomy in ST-segment Elevation Myocardial Infarction

    Abstract
    Issue3-4
    Published
    Pages95
    PDF via DOIhttps://doi.org/10.15836/ccar2016.95
    mechanical thrombectomy
    primary PCI
    ST-segment elevation myocardial infarction

    Authors

    Luka Bastiančić*ORCIDUniversity of Rijeka School of Medicine, University Hospital Centre Rijeka, Rijeka, Croatia
    Gordana BačićORCIDUniversity of Rijeka School of Medicine, University Hospital Centre Rijeka, Rijeka, Croatia
    David GobićORCIDUniversity of Rijeka School of Medicine, University Hospital Centre Rijeka, Rijeka, Croatia
    Tomislav JakljevićORCIDUniversity of Rijeka School of Medicine, University Hospital Centre Rijeka, Rijeka, Croatia

    *Correspondence email: lbastiancic@hotmail.com

    Full Text

    Introduction: Occlusive thrombus due to ruptured or eroded atherosclerotic plaque is the most frequent substrate for ST-segment elevation myocardial infarction (STEMI). Distal embolization of intracoronary thrombus results in microvascular obstruction and compromised TIMI (Thrombolysis In Myocardial Infarction) flow. Forceful coronary injections, passage of intracoronary devices, initial balloon angioplasty and/or stenting induce distal embolization. Intracoronary thrombus additionally may contribute to vessel and stent undersizing increasing the risk of stent malapposition, in-stent restenosis or stent thrombosis. (1–3)

    Case presentation: We present an 81-year-old Caucasian male with STEMI with rapid progression to cardiogenic shock and cardiorespiratory arrest during diagnostic coronary angiography. Severe stenosis of right coronary artery (RCA) with occlusive thrombus of the left main (LM) was found. The patient received a veno-arterial extracorporeal membrane oxygenation (ECMO) device. We performed a standard percutaneous coronary intervention (PCI) of RCA and rheolytic thrombectomy (AngioJet™) of the LM. The patient was successfully weaned from ECMO 29 hours after the procedure, with no inoconstrictor support. After nine days he was fully mobilized with no neurological deficit and a 40% left ventricular ejection fraction on echocardiography.

    Conclusion: Current evidence does not support the routine use of rheolytic thrombectomy in primary PCI. In specific cases that are involving large occlusive thrombus it may be a therapy of choice.

    Literature

    1. 1.
      Parodi G, Valenti R, Migliorini A, Maehara A, Vergara R, Carrabba N, et al. Comparison of manual thrombus aspiration with rheolytic thrombectomy in acute myocardial infarction. Circ Cardiovasc Interv. 2013;6(3):224–30.DOI
    2. 2.
      Beran G, Lang I, Schreiber W, Denk S, Stefenelli T, Syeda B, et al. Intracoronary thrombectomy with the X-sizer catheter system improves epicardial flow and accelerates ST-segment resolution in patients with acute coronary syndrome: a prospective, randomized, controlled study. Circulation. 2002;105:2355–60.DOI
    3. 3.
      Antoniucci D, Valenti R, Migliorini A, Parodi G, Memisha G, Santoro GM, et al. Comparison of rheolytic thrombectomy before direct infarct artery stenting versus direct stenting alone in patients undergoing percutaneous coronary intervention for acute myocardial infarction. Am J Cardiol. 2004;93:1033–5.DOI