Left atrial stiffness index correlates with atrial fibrillation recurrence in patients who underwent electrical cardioversion

    Authors

    Keywords

    left atrium, atrial fibrillation, fibrosis, prediction

    DOI

    https://doi.org/10.15836/ccar2024.494

    Full Text

    **Introduction:** Left atrial (LA) remodeling is a complex anatomical and functional process in response to electrical, mechanical and metabolic disturbances. LA remodeling is usually a consequence of LA volume overload, left ventricular systolic dysfunction and physiological aging process. LA remodeling directly correlates with atrial fibrillation occurrence. (1-3) Aim: To analyze left atrial strain parameters for the purpose of prediction of atrial fibrillation (AF) after the electrical cardioversion. **Patients and Methods:** Analysis included 31 patients, who underwent electrical cardioversion due to AF at the Department of Cardiology, General Hospital “Prim. Dr. Abdulah Nakaš” in the period from May 2023 until May 2024. Transthoracic and transesophageal echocardiogram was performed in all patients, regardless of the previous anticoagulation therapy. **Results:** There was a statistically significant correlation between the recurrence of AF three months and six months after the electrical cardioversion and the following echocardiographic parameters: LA reservoir strain (p<0.001; p=0.001), LA conduit strain (p<0.001, p=0.001), LA contractile strain (p<0.001; p<0.001), E/e’ ratio (p<0.001, p=0.001), and left atrial stiffness index (p<0.001; p=0.004). Left atrial volume index did not significantly correlate with AF recurrence within three and six months after the cardioversion. **Conclusion:** Patient risk stratification for AF recurrence could be made based on LA strain parameters.

    Literature

    1. Begic Z, Djukic M, Begic E, Aziri B, Gojak R, Mladenovic Z, et al. Left atrial stiffness is in correlation with left atrial reservoir strain in pediatric patients with mitral regurgitation. Technol Health Care. 2024;32(5):3525–33. https://doi.org/10.3233/THC-240402
    2. Yafasov M, Olsen FJ, Hauser R, Skaarup KG, Lassen MCH, Johansen ND, et al. Left atrial strain measured by three-dimensional echocardiography predicts atrial fibrillation in the general population. Int J Cardiol. 2024 September 12;417:132544. https://doi.org/10.1016/j.ijcard.2024.132544
    3. Liu T, Yang X, Jia R, Han J, Gu X, Liu P, et al. Left atrial mechanical dispersion and left atrial stiffness predicts recurrence of atrial fibrillation: In patients with moderate-severe rheumatic mitral stenosis. Int J Cardiol. 2024 December 1;416:132480. https://doi.org/10.1016/j.ijcard.2024.132480
    Cardiologia Croatica
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    Left atrial stiffness index correlates with atrial fibrillation recurrence in patients who underwent electrical cardioversion

    Extended Abstract
    Issue11-12
    Published
    Pages494
    PDF via DOIhttps://doi.org/10.15836/ccar2024.494
    left atrium
    atrial fibrillation
    fibrosis
    prediction

    Authors

    Nejra Mlačo-Vražalić*ORCIDGeneral Hospital “Prim. Dr. Abdulah Nakaš”, Sarajevo, Bosnia and Herzegovina
    Denis MačkićORCIDGeneral Hospital “Prim. Dr. Abdulah Nakaš”, Sarajevo, Bosnia and Herzegovina
    Jasmin IdrizovićORCIDGeneral Hospital “Prim. Dr. Abdulah Nakaš”, Sarajevo, Bosnia and Herzegovina
    Bilal OglečevacORCIDGeneral Hospital “Prim. Dr. Abdulah Nakaš”, Sarajevo, Bosnia and Herzegovina
    Ada ĐozićORCIDGeneral Hospital “Prim. Dr. Abdulah Nakaš”, Sarajevo, Bosnia and Herzegovina
    Buena AziriORCIDSarajevo Medical School, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina
    Amer IglicaClinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
    Zijo BegićORCIDClinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
    Nirvana Šabanović-BajramovićORCIDClinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina
    Edin BegićORCIDGeneral Hospital “Prim. Dr. Abdulah Nakaš”, Sarajevo, Bosnia and Herzegovina

    *Correspondence email: nejra.ml@gmail.com

    Full Text

    Introduction: Left atrial (LA) remodeling is a complex anatomical and functional process in response to electrical, mechanical and metabolic disturbances. LA remodeling is usually a consequence of LA volume overload, left ventricular systolic dysfunction and physiological aging process. LA remodeling directly correlates with atrial fibrillation occurrence. (1–3) Aim: To analyze left atrial strain parameters for the purpose of prediction of atrial fibrillation (AF) after the electrical cardioversion.

    Patients and Methods: Analysis included 31 patients, who underwent electrical cardioversion due to AF at the Department of Cardiology, General Hospital “Prim. Dr. Abdulah Nakaš” in the period from May 2023 until May 2024. Transthoracic and transesophageal echocardiogram was performed in all patients, regardless of the previous anticoagulation therapy.

    Results: There was a statistically significant correlation between the recurrence of AF three months and six months after the electrical cardioversion and the following echocardiographic parameters: LA reservoir strain (p<0.001; p=0.001), LA conduit strain (p<0.001, p=0.001), LA contractile strain (p<0.001; p<0.001), E/e’ ratio (p<0.001, p=0.001), and left atrial stiffness index (p<0.001; p=0.004). Left atrial volume index did not significantly correlate with AF recurrence within three and six months after the cardioversion.

    Conclusion: Patient risk stratification for AF recurrence could be made based on LA strain parameters.

    Literature

    1. 1.
      Begic Z, Djukic M, Begic E, Aziri B, Gojak R, Mladenovic Z, et al. Left atrial stiffness is in correlation with left atrial reservoir strain in pediatric patients with mitral regurgitation. Technol Health Care. 2024;32(5):3525–33.DOI
    2. 2.
      Yafasov M, Olsen FJ, Hauser R, Skaarup KG, Lassen MCH, Johansen ND, et al. Left atrial strain measured by three-dimensional echocardiography predicts atrial fibrillation in the general population. Int J Cardiol. 2024 September 12;417:132544.DOI
    3. 3.
      Liu T, Yang X, Jia R, Han J, Gu X, Liu P, et al. Left atrial mechanical dispersion and left atrial stiffness predicts recurrence of atrial fibrillation: In patients with moderate-severe rheumatic mitral stenosis. Int J Cardiol. 2024 December 1;416:132480.DOI