Authors

• Karolina Beg — University of Zagreb, Zagreb, Croatia — ORCID: 0009-0009-6670-9956
• Sandra Jakšić Jurinjak — University of Zagreb, Zagreb, Croatia — ORCID: 0000-0002-7349-6137
• Andro Koren — University of Zagreb, Zagreb, Croatia — ORCID: 0009-0006-7586-1624
• Luciana Koren — University of Zagreb, Zagreb, Croatia — ORCID: 0009-0002-1994-3511
• Vice Zubak — University of Zagreb, Zagreb, Croatia — ORCID: 0009-0004-0688-7834
• Vlatka Rešković Lukšić — University of Zagreb, Zagreb, Croatia — ORCID: 0000-0002-4721-3236
• Marija Brestovac — University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0003-1542-2890
• Martina Lovrić Benčić — University of Zagreb, Zagreb, Croatia — ORCID: 0000-0001-8446-6120
• Joško Bulum — University of Zagreb, Zagreb, Croatia — ORCID: 0000-0002-1482-6503
• Zvonimir Ostojić — University of Zagreb, Zagreb, Croatia — ORCID: 0000-0003-1762-9270
• Blanka Glavaš Konja — University Hospital Centre Zagreb, Zagreb, Croatia — ORCID: 0000-0003-1134-4856
• Jadranka Šeparović Hanževački — University of Zagreb, Zagreb, Croatia — ORCID: 0000-0002-3437-6407

Keywords

aortic valve stenosis, atrial fibrillation, renal insufficiency, risk factors

DOI

Full Text

**Introduction:** Chronic kidney disease negatively impacts valves by increasing the incidence of calcifications on the valves and mortality. (1, 2) The goal of the study was to examine the correlation between severe aortic stenosis (AS), its risk factors and kidney function. **Patients and Methods:** The retrospective study included 548 patients with severe AS, admitted from September 2020 to August 2024 at our Heart Valve Department. More patients were female (54%, N=296). 38 patients were 75 years old (N=385). Mean ejection fraction of the left ventricle (EFLV) was 51.501±11.502 [15-80], and mean eGFR was 59.549±22.322. They were divided into three groups (terciles) according to estimated glomerular filtration rate (eGFR): the 1st group included those with eGFR ≤49 mL/min/1.73m2, the 2nd group consisted of patients with eGFR 50-72 mL/min/1.73m2, while the 3rd group was composed of patients with eGFR >72 mL/min/1.73m2. We compared eGFR and risk factors: arterial hypertension (AH), diabetes mellitus (DM), smoking, dyslipidemia (DIS) and body mass index (BMI). Additionally, we compared eGFR groups and atrial fibrillation (AF), coronary artery disease, and coexisting multivalvular disease (mitral/tricuspid valve regurgitation, mitral valve stenosis). **Results:** Standard cardiovascular risk factors: AH, DM, and DIS were more common in the 1st group (patients with severe AS and eGFR values ≤49 mL/min/1.73m2) compared to the 3rd group (patients with eGFR >72 mL/min/1.73m2) (respectively P2, 1st and 2nd group compared to 3rd group (P=0.013). When comparing coexisting multivalvular disease, the 1st with the 3rd group, mitral valve regurgitation (MR) showed a positive tendency for significance (P=0.05). No statistically significant correlation was observed between BMI and eGFR in patients (P=0.07, Pearson correlation test: r=0.027, P=0.53). When comparing patients by age, those >75 years old, had a lower eGFR compared to younger groups, as expected (P2 are older, and more commonly have AH, DM, DIS, and mitral valve involvement marked as MR. Moreover, even those with eGFR ≤72 mL/min/1.73m2 can have a greater risk for AF.

Literature

1. Vavilis G, Bäck M, Occhino G, Trevisan M, Bellocco R, Evans M, et al. Kidney dysfunction and the risk of developing aortic stenosis. J Am Coll Cardiol. 2019 January;73(3):305–14. https://doi.org/10.1016/j.jacc.2018.10.068
2. Bohbot Y, Candellier A, Diouf M, Rusinaru D, Altes A, Pasquet A, et al. Severe Aortic Stenosis and Chronic Kidney Disease: Outcomes and Impact of Aortic Valve Replacement. J Am Heart Assoc. 2020 October 20;9(19):e017190. https://doi.org/10.1161/JAHA.120.017190