Investigating the effect of fructose on glucose, insulin, adiponectin, leptin and triglyceride tolerance in adult laboratory rats

    Authors

    Keywords

    fructose, obesity, insulin resistance

    DOI

    https://doi.org/10.15836/ccar2021.37

    Full Text

    Introduction : The metabolic syndrome over recent years is being actively studied and is in the focus of experimental and clinical studies. Insulin resistance cause major problem in metabolism and is related not only to obesity but also to the pathogenesis of type 2 diabetes, cardiovascular disease, etc. ( 1 - 3 ) Purpose: The effect of fructose on body weight in experimental adult rats and the effect of fructose on the content of glucose, triglycerides, uric acid, insulin, adiponectin and leptin in the blood of experimental animals. Material and Methods : The study was performed on 12 adult male rats divided into two groups: control group and fructose group. Experimental animals were treated daily in a period of 8 weeks with 10% fructose solution, 1ml/100g by mouth (per os). While, the control group of animals was treated with a vehiculum (physiological digestion). Results : Table 1 are presented the changes in body weight of experimental animals under the influence of fructose. Statistically significant (p<0.05) is the weight of fructose-treated experimental animals compared to the control group at the end of the experiment. Table 2 presents the results from the definition of other indicators. The animal blood glucose levels are elevated treated with glucose compared to the control group. Statistically significant is the increase in blood of the triglyceride levels after 8 weeks of glucose treatment. Conclusions : The analysis of insulin elevation and blood sugar rise gives us reasons for the development of “insulin resistance” under the influence of fructose. At the experimental animals cannot be demonstrated the effect of insulin elevation, and fasting blood sugar is elevated after 8-week treatment with fructose.

    Cardiologia Croatica
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    Investigating the effect of fructose on glucose, insulin, adiponectin, leptin and triglyceride tolerance in adult laboratory rats

    Extended Abstract
    Issue1-2
    Published
    Pages37
    PDF via DOIhttps://doi.org/10.15836/ccar2021.37
    fructose
    obesity
    insulin resistance

    Authors

    Besim Memedi*ORCID
    Agron ZuferiORCID

    Full Text

    Introduction : The metabolic syndrome over recent years is being actively studied and is in the focus of experimental and clinical studies. Insulin resistance cause major problem in metabolism and is related not only to obesity but also to the pathogenesis of type 2 diabetes, cardiovascular disease, etc. ( 1 - 3 ) Purpose: The effect of fructose on body weight in experimental adult rats and the effect of fructose on the content of glucose, triglycerides, uric acid, insulin, adiponectin and leptin in the blood of experimental animals. Material and Methods : The study was performed on 12 adult male rats divided into two groups: control group and fructose group. Experimental animals were treated daily in a period of 8 weeks with 10% fructose solution, 1ml/100g by mouth (per os). While, the control group of animals was treated with a vehiculum (physiological digestion). Results : Table 1 are presented the changes in body weight of experimental animals under the influence of fructose. Statistically significant (p<0.05) is the weight of fructose-treated experimental animals compared to the control group at the end of the experiment. Table 2 presents the results from the definition of other indicators. The animal blood glucose levels are elevated treated with glucose compared to the control group. Statistically significant is the increase in blood of the triglyceride levels after 8 weeks of glucose treatment. Conclusions : The analysis of insulin elevation and blood sugar rise gives us reasons for the development of “insulin resistance” under the influence of fructose. At the experimental animals cannot be demonstrated the effect of insulin elevation, and fasting blood sugar is elevated after 8-week treatment with fructose.