Authors

• Besim Memedi — State University of Tetova, Tetovo, North Macedonia — ORCID: 0000-0002-2383-5452
• Agron Zuferi — General Hospital “Ferid Murad” Gostivar, Gostivar, North Macedonia — ORCID: 0000-0002-1038-1519

Abstract

**Introduction**: The metabolic syndrome over recent years is being actively studied and is in the focus of experimental and clinical studies. Insulin resistance cause major problem in metabolism and is related not only to obesity but also to the pathogenesis of type 2 diabetes, cardiovascular disease, etc. (1-3) Purpose: The effect of fructose on body weight in experimental adult rats and the effect of fructose on the content of glucose, triglycerides, uric acid, insulin, adiponectin and leptin in the blood of experimental animals. **Material and Methods**: The study was performed on 12 adult male rats divided into two groups: control group and fructose group. Experimental animals were treated daily in a period of 8 weeks with 10% fructose solution, 1ml/100g by mouth (per os). While, the control group of animals was treated with a vehiculum (physiological digestion). **Results**: **Table 1** are presented the changes in body weight of experimental animals under the influence of fructose. Statistically significant (p<0.05) is the weight of fructose-treated experimental animals compared to the control group at the end of the experiment. **Table 2** presents the results from the definition of other indicators. The animal blood glucose levels are elevated treated with glucose compared to the control group. Statistically significant is the increase in blood of the triglyceride levels after 8 weeks of glucose treatment. ### TABLE 1: Influence of fructose on body weight of adult male mice. | **Group** | **Weight at the beginning of the experiment (g)** | **Weight at the end of the experiment (g)** | | --- | --- | --- | | K (n=6) | 130.0 ± 30.0 | 180.0 ± 33.0 | | H (n=6) | 132.0 ± 25.0 | 250.0 ± 40.0* | ### TABLE 2: Impact of fructose on glucose, triglyceride, uric acid, insulin, adiponectin and leptin contents in experimental animal blood. | **Group** | **Group** | **Glucose** **(mmol/L)** | **Triglycerides** **(mmol/L)** | **Uric acid** **(mg/dL)** | **Uric acid** **(mg/dL)** | **Uric acid** **(mg/dL)** | **Insulin** **(ng/ml)** | **Adiponektin** **(ng/ml)** | **Leptin** **(ng/ml)** | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | K (n=6) | 6.0 ± 0.4 | | 1.2 ± 0.03 | | 3.7 ± 0.2 | 2.8 ± 0.3 | | 6.0 ± 2.1 | 28.7 ± 3.1 | | H (n=6) | 18.2 ± 1.2* | | 4.6 ± 0.3* | | 6.5 ± 1.1* | 3.5 ± 1.8* | | 2.4 ± 0.05* | 35.9 ± 4.0* | **Conclusions**: The analysis of insulin elevation and blood sugar rise gives us reasons for the development of “insulin resistance” under the influence of fructose. At the experimental animals cannot be demonstrated the effect of insulin elevation, and fasting blood sugar is elevated after 8-week treatment with fructose.

Keywords

fructose, obesity, insulin resistance

DOI

Literature

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