Authors

• Azra Durak-Nalbantić — University Clinical Center of Sarajevo, Sarajevo, Bosnia and Herzegovina — ORCID: 0000-0002-5175-8941
• Mirza Dilić — University Clinical Center of Sarajevo, Sarajevo, Bosnia and Herzegovina — ORCID: 0000-0002-7309-1455
• Faris Zvizdić — University Clinical Center of Sarajevo, Sarajevo, Bosnia and Herzegovina — ORCID: 0000-0001-7647-2723
• Alen Džubur — University Clinical Center of Sarajevo, Sarajevo, Bosnia and Herzegovina — ORCID: 0000-0003-1198-540X
• Marina Vučijak — University Clinical Center of Sarajevo, Sarajevo, Bosnia and Herzegovina — ORCID: 0000-0002-3755-0968
• Nerma Resić — University Clinical Center of Sarajevo, Sarajevo, Bosnia and Herzegovina — ORCID: 0000-0002-8499-457X

Abstract

**Introduction:** Up to 50% of patients with acute heart failure (AHF) have preserved left ventricular ejection fraction (HFPEF group) (1). Due to diverse activated pathophysiological pathways, there should be a difference in biomarkers release in heart failure with preserved ejection fraction (HFPEF) and reduced ejection fraction (HFREF). BNP is the best studied biomarker in AHF, but we want to investigate difference in release of troponin (marker of myocytes stress and injury), tumor marker CA125 (marker of congestion and volume overload om HF) and cystatin C (marker of interstitial fibrosis). **Patients and Methods:** In 222 patients hospitalized due to acute heart failure (138 with REF and 74 with PEF) were determined levels of BNP at admission („dry BNP“), BNP at discharge („wet BNP“), procentual change of BNP during hospitalization, high sensitive troponin I, cystatin C and CA125. **Results**: BNP at admission is lower in HFREF vs HFPEF group [1254.9 (732.7-2402.6) pg/ml vs 479.9 (240.7-865.7) pg/ml, p.**

Keywords

biomarkers, acute heart failure

DOI

Literature

1. Savarese G, Lund LH. Global Public Health Burden of Heart Failure. Card Fail Rev. 2017 Apr;3(1):7–11. https://doi.org/10.15420/cfr.2016:25:2
2. Jacob J, Roset A, Miró Ò, Alquézar A, Herrero P, Martín-Sanchez FJ, et al. EAHFE - TROPICA2 study. Prognostic value of troponin in patients with acute heart failure treated in Spanish hospital emergency departments. Biomarkers. 2017 May - Jun;22(3-4):337–44. https://doi.org/10.1080/1354750X.2016.1265006
3. Sanders-van Wijk S, van Empel V, Davarzani N, Maeder MT, Handschin R, Pfisterer ME, et al. Circulating biomarkers of distinct pathophysiological pathways in heart failure with preserved vs. reduced left ventricular ejection fraction. Eur J Heart Fail. 2015 Oct;17(10):1006–14. https://doi.org/10.1002/ejhf.414