Biomarkers in heart failure

    Authors

    Keywords

    biomarker, heart failure, NT-proBNP

    DOI

    https://doi.org/10.15836/ccar2018.352

    Full Text

    Over the past few years, we are witnessing a great progress in the treatment of heart failure (HF), as well as in the development of cardiac biomarkers. Intriguing interaction of various mechanisms, involving neurohumoral activation, inflammation, pressure/volume ventricular load, myocardial remodeling and myocardial lesion, lead to heart failure development. Natriuretic peptide testing is commonly used in routine clinical practice. It has a paramount role in the diagnosis and prognosis of HF as well as well-known significance in treatment-guided therapy. Knowing the complexity of HF pathophysiological process, new biomarkers have emerged that can replace the usual ones. ( 1 - 3 ) The aim of this paper is to compare natriuretic peptides, ST2, galectin-3, and highly sensitive troponin. It is reasonable to expect that the future will bring a multibiomarker panel as a necessary tool to improve HF understanding as well as better treatment of HF patients.

    Cardiologia Croatica
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    Biomarkers in heart failure

    Extended Abstract
    Issue11-12
    Published
    Pages352
    PDF via DOIhttps://doi.org/10.15836/ccar2018.352
    biomarker
    heart failure
    NT-proBNP

    Authors

    Ivica Bošnjak*ORCIDUniversity Clinical Centre Osijek, Osijek, Croatia
    Dražen BedekovićORCIDUniversity Clinical Centre Osijek, Osijek, Croatia

    Full Text

    Over the past few years, we are witnessing a great progress in the treatment of heart failure (HF), as well as in the development of cardiac biomarkers. Intriguing interaction of various mechanisms, involving neurohumoral activation, inflammation, pressure/volume ventricular load, myocardial remodeling and myocardial lesion, lead to heart failure development. Natriuretic peptide testing is commonly used in routine clinical practice. It has a paramount role in the diagnosis and prognosis of HF as well as well-known significance in treatment-guided therapy. Knowing the complexity of HF pathophysiological process, new biomarkers have emerged that can replace the usual ones. ( 1 - 3 ) The aim of this paper is to compare natriuretic peptides, ST2, galectin-3, and highly sensitive troponin. It is reasonable to expect that the future will bring a multibiomarker panel as a necessary tool to improve HF understanding as well as better treatment of HF patients.